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Information × Registration Number 0219U006447, 0116U006026 , R & D reports Title Comprehensive analysis of modified and unmodified risk factors for cognitive impairment of neurodegenerative (Alzheimer's) and vascular genesis popup.stage_title Head Bachinska Natalia, Доктор медичних наук Registration Date 18-11-2019 Organization State Institute of Gerontology of the Ukrainian Academy of Medical Sciences popup.description2 The results of the studies (according to the MMSE) indicate a characteristic change in the percentage distribution of people over 60 years of age, depending on age and cognitive abilities - an increase in the proportion of people with moderate cognitive impairment and dementia against the background of a significant decrease in the proportion of people with unchanged levels unchanged proportion of people with age-dependent memory impairment. The formation of cognitive deficits in the early stages of dementia has its own characteristics, depending on the etiological factor, namely neurodegenerative or vascular. Thus, at the beginning of the clinical manifestations of HA there is a deterioration of memory function (especially episodic) and ability to generalize. In the cognitive profile, there is a significant advantage of changes in the parameters that characterize episodic memory over the parameters of the ability to generalize. Further development of the disease is accompanied by a more pronounced deterioration of the various components of mystical function, attention, praxis and gnosis and, as a consequence, general intellectual abilities with a decrease in the ability of mental generalizations and abstract thinking. In the initial stage of diabetes, changes in executive functions are at the forefront, with a certain preservation of mastic characteristics. The patients examined correlated the level of blood pressure, glycemia, triglyceride content and total MMSE score. In middle-aged patients, higher levels of systolic blood pressure and glycemia were associated with poorer cognitive performance. In old age, increased systolic blood pressure, blood glucose and triglyceride content were accompanied by a decrease in cognitive parameters. The data obtained substantiate the possibility of using elevated levels of triglycerides and glucose in the blood, as well as increased levels of blood pressure as prognostic factors for cognitive decline in middle and elderly patients. A history of poorly controlled hypertension, type 2 diabetes, depressive symptoms, smoking, and a low level of education significantly increase the risk of developing cognitive impairment of Alzheimer's and vascular type. One-way ANOVA was performed to identify the association between ApoE gene polymorphism and the development of cognitive impairment in the subjects studied. It was found that the presence of the ApoE? 4 allele was associated with a higher degree of cognitive deficit according to the overall MMSE score. The relationship of telomere length with age-dependent cognitive decline was revealed. The effectiveness of the treatment of cognitive impairment in dementia with donepezil hydrochloride and memantine may largely be related to the existing ApoE genotype, which makes it advisable to determine the apoE gene polymorphism in patients with cognitive deficits. Product Description popup.authors Бачинська Наталія Юріївна Копчак Оксана Олегівна Холін Віктор Олександрович popup.nrat_date 2020-04-02 Close