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Registration Number

0219U100039, 0116U001604 , R & D reports

Title

Theoretical and methodological justification for the use of new potential antifungal agents - nitrogen-bearing heterocyclic compounds

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Head

Voloshchuk Nаtаliia M., Кандидат біологічних наук

Registration Date

09-01-2019

Organization

National University of Life and Environmental Sciences of Ukraine

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3. The object of study is new potential antifungal agents – nitrogen-bearing heterocyclic compounds; cereals – wheat, barley, corn; fungi – plant disease agents: Fusarium sp., Alternaria sp., Aspergillus sp., Penicillium sp. The aim of the study is theoretical and methodological justification for the use of new potential antifungal agents – nitrogen-bearing heterocyclic compounds in plant protection. Research methods include traditional and modified methods of chemical synthesis, modern methods of molecular biology, the method of molecular docking, classical and modified microbiological and phytopathological methods. Compounds that reliably inhibited the functioning of the model transcription system have been identified. Among them, 9 test agents were found, for which the ІС50 indicator was in the range of 20-1 μM. As a result of the research conducted, different sensitivity of micromycetes isolated from wheat, barley, and corn seeds to synthesized substances in a concentration of 1 mg/ml was determined. Preparations derived from quinolones and amides of acridoncarboxylic acids delayed the growth of the species Aspergillus flavus, A. fumigatus, A. nidulans, A. niger and Penicillium brevicompactum, and also changed fungal morphology. Growth inhibition of representatives of the genera Alternaria and Fusarium was observed with compounds derived from azapirimidines, quinolones, and lectins. The results of studies of antifungal and antimicrobial activity demonstrated the perspectives of using quinolones and acridones as substances with a broad spectrum of action. Area of using – agriculture, biotechnology. 

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2020-04-02