Search academic texts

Information × Registration Number 0219U100318, 0118U100166 , R & D reports Title Development of scientific foundations of magneto-sensitive nanocomposites for local chemo- and immunotherapy of hepatocellular carcinoma and intrahepatic cholangiocarcinoma popup.stage_title Head Gorbyk Petro P., Доктор фізико-математичних наук Registration Date 05-02-2019 Organization Chuiko Institute of Surface Chemistry of NAS of Ukraine popup.description2  In order to create new magnetically sensitive colloidal systems with oncological preparations of the chemo-therapeutic and immunotherapeutic mechanism of action against the tumors of the fcc and VPKK, the basic nanotechnological stages of the chemical construction of nanostructured biocompatible composite materials are worked out. Magnetically sensitive colloidal systems based on nanosized singledomain magnetite, stabilized with sodium oleate and modified with polyethylene glycol were synthesized. The control of the parameters of magnetic fluids was carried out using vibration magnetometry, X-ray diffraction analysis, IR-Fourier spectroscopy, and transmissive electron microscopy. Colloids are characterized as polydispersions with particle sizes of 2 to 22 nm (maximum distribution ~ 13.78 ± 2.93 nm). Magnetically sensitive colloidal vector systems with immobilized oncology gemcitabine conjugated with HER2 antibodies against FSH tumors were created, their cytotoxic activity in vitro was investigated. The effectiveness of the cytotoxic action of the synthesized samples on the viability of hepatocellular hepatocellular carcinoma HepG2 cells cells was studied. It has been shown that the colon system MR / GC / HER2 causes a synergistic antitumor effect and increases the cytotoxic activity of gemcitabine by ~ 20%, which allows to achieve the cytotoxic effect of the drug at lower concentrations, reducing the toxic effect of gemcitabine on the body as a whole. Product Description popup.authors popup.nrat_date 2020-04-02 Close