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Information × Registration Number 0219U100345, 0118U001600 , R & D reports Title Analysis of the signaling pathways associated with glutamine metabolism in radioresistant prostate cancer. popup.stage_title Head Telegeev Gennadiy D., Доктор біологічних наук Registration Date 07-02-2019 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2 From the created bank of tumor tissues and adjacent normal tissues, RNA and DNA were isolated, data and therapy for patients have been collected. Specific oligonucleotide primers for genes (ALDH5A1, GDH, GcLc), which determine tumor cell metabolism were synthesized. The level of expression of c-myc, GLS 1, Krt 5 genes was evaluated by real-time reverse transcriptase RT-PCR method, western blot. Controversial results were obtained for this samples, the only significant increase in cytokeratin 5 in metastatic tissue was noted. This necessitates an increasing number of samples and an increase in the number of genes for analyzing the pathways of glutamine metabolism. Product Description popup.authors popup.nrat_date 2020-04-02 Close