Search academic texts

Information × Registration Number 0219U101305, 0119U101935 , R & D reports Title Research of the auxiliary substances choice and studying of their influence on the pharmaco-technological properties of suppositories with probiotic activity popup.stage_title Head Polova Zhanna М., Кандидат фармацевтичних наук Registration Date 04-07-2019 Organization Bogomolets National Medical University, Ministry of Health of Ukraine popup.description2  For the first time, the study of the physico-chemical properties of the substance Lactobacillus casei ІМВ В-7280 and found that the substance is a powder of brick color, with a weak specific odor, hygroscopic, which forms agglomerates of different sizes. The results of solubility studies of lactobacillus powder showed that it was practically insoluble in glycerol, polysorbate-80, macrogol, sunflower oil, peach oil. The substance is soluble in water while stirring. For the first time, the fractional composition of the powder has been determined. It has been established that the powder has a polydispersed composition capable of agglomeration, which may have a negative effect on the homogeneity of the dosage and degree of sedimentation. Samples of vaginal suppositories complying with the requirements of the State Pharmacopoeia in terms of "homogeneity", "melting point" and "time of disintegration" are obtained. The spectrum of auxiliary substances providing the maximum preservation of viability of probiotic strains of bacteria is determined. The stability of suppositories during storage is researched. In terms of: appearance, average mass, disintegration time, homogeneity, melting point, experimental specimens found stability at two temperature regimes: 8.0-15.0 ° C and 15.0-25.0 ° C for 6 months of storage. Product Description popup.authors Glushenko Olena M. Polova Zhanna M. popup.nrat_date 2020-04-02 Close