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Information × Registration Number 0219U102058, 0119U103387 , R & D reports Title Toxico-biochemical assessment of metal nanoparticles – potential components of biological preparations and feed additives for animals popup.stage_title Head Orobchenko Oleksandr L., Registration Date 16-12-2019 Organization National Scientific Center Institute of Experimental and Clinical Medicine popup.description2  As a result of the studies, the mechanism of the toxic action of the NPMe mixture for the introduction of chickens at a dose of 4.0 mg / kg body weight was first established, which is to reduce natural resistance, excess formation of toxic products of purine metabolism and strain of enzyme systems of natural detoxification with the development of oxidative stress diene conjugates and malondialdehyde by 19.3 and 23.8%; P <0.01) in the body of daily chickens. The mechanism of pharmacological action of the NPMe mixture for the administration of 0.3 mg / kg body weight to chickens is to enhance immune responses (increase in total globulin by 12.0%; P <0.05) along with antioxidant effects through release from endogenous vitamin depots A and E (14.7 and 25.7% higher relative to control; P <0.05) in daily chickens. Based on the generalization and retrospective analysis of the results of previous studies (toxicological experiments) to study the safety, biocompatibility and bioavailability of experimental samples of metal nanoparticles in comparison with their ionic form on the model of pro- and eukaryotic cells, laboratory animals, laying hens, their embryos of poultry products (egg, meat) the methodology of safety and biocompatibility assessment of metal nanoparticles under conditions of application in modern poultry farming with the purpose of prof. ilacs of their possible negative impact on animals. " The mechanism of toxic action of the mixture NPMe at a dose of 4.0 mg / kg body weight is established will allow to develop safe regulations for their use in modern poultry farming and to manage risks of application in a timely manner. The introduction of a mixture of NPMe (Ag, Cu, Fe, MnO2) at a dose of 0.3 mg / kg body weight of laying hens can help to obtain a high percentage of safety of young birds, the formation of protective reactions in the body of chickens and to ensure the full realization of genetic potential for meat or egg productivity. Product Description popup.authors Roman'ko Marina Ye. popup.nrat_date 2020-04-02 Close