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Information × Registration Number 0219U102403, 0117U000099 , R & D reports Title Synthesis and research of derivatives of fused heterocyclic systems with pyrimidine core popup.stage_title Head Smolii Oleg B., Доктор хімічних наук Registration Date 28-12-2019 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 Effective methods for the synthesis of 4-aminosubstituted pyrrolo[2,3-d]pyrimidine-6-carboxylic acids have been developed and the interaction of 4-functionally substituted 7-deazapurine derivatives with iodine has been studied. It was shown that the iodination reaction products of 4-methoxypyrrolo[2,3-d]pyrimidine-6-carboxylic acid and its methyl ester proved to be convenient reagents for the preparation of a new tricyclic system with the pyrrolo[2,3-d]pyrimidine moiety – 2a,5a,7-triazaacenaphthylene. On the basis of 4-amino-substituted 8-(iodomethyl)pyrimido[5',4':4,5]-pyrrolo[2,1-c][1,4]oxazines, an effective method for the synthesis of previously unknown tricyclic derivatives of 1-deazapyrimido[1,2,3-cd]purine – 4,5-dihydro-3H-2a,7-diaza-5a-azoniaacenaphthylenes. The results obtained can be used to specifically search for inhibitors of nucleic acid synthesis enzymes. Product Description popup.authors Biletskii Igor І. Verves Evgeniy V. Gaevsky Anatoly Р. Zinchenko Hanna M. Kukuyev Maksym О. Kucher Oleksandr V. Muzychka Lyubov V. Yaremchuk Iryna О. popup.nrat_date 2020-04-02 Close