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Information × Registration Number 0220U000078, 0117U004313 , R & D reports Title The research of the ability to formation of biofilm formations and patothenic properties of pathogens of infectious-inflammatory complications in patients with acute leukemia and defining the role of probiotic preparations in the destruction of microbial biofilms popup.stage_title Head Rybalska A.P., Registration Date 13-01-2020 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Object of study. 47 people: 31 patients with AL, 5 - comparison group; 11 - control group, 381 isolated strain of microorganisms. Research methods: laboratory-clinical, hematological, immunocytochemical, microbiological, immunological. Arm. To determine the factors of influence of probiotic drugs on the disintegration processes of microbial communities of conditionally pathogenic microorganisms - probable or obvious causative agents of infectious-inflammatory complications in patients with leukemia. Results. The positive effect of probiotic drugs on the restoration of the intestinal microflora and the elimination of conditionally pathogenic microorganisms from the upper respiratory tract (URT) and intestine biotypes has been shown. The use of probiotics allowed to detect "hidden pathogens" in URT biotopes -the microorganisms that were not isolated at the beginning of the study but were detected after the use of probiotics in clinically relevant titers. Additionally installed what influence of multicomponent probiotic on the process of inhibition of adhesion of staphylococci, reduction of pathogenic potential of these microorganisms, which prevents their colonization resistance. Against the background of its application, the restoration of population and subpopulation composition of peripheral blood lymphocytes of patients and activation of the final stage of phagocytosis of neutrophilic granulocytes were revealed. Thus, the appointment of a multicomponent probiotic for concomitant therapy for patients with AL has a positive effect on the elimination of dysbiotic conditions, normalization of microecology of biotopes, increase of anti-infectious immunity and, as a consequence, it helps to prevent the development of infectious-inflammatory complications, what gives the opportunity to carry out treatment in full. Medico-social effect. Medicine. Product Description popup.authors Кисельова О.А. Мельник О.А. Немировська Л.М. Павлюк Л.П. Скачкова Н.К. Тимошенко У.В. Третяк Н.М. popup.nrat_date 2020-04-02 Close