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Information × Registration Number 0220U100194, 0118U003771 , R & D reports Title The analysis of neuroendocrinological effects of prenatal exposure by incorporated 131І popup.stage_title Head Kaminskiy Oleksyi V., Доктор медичних наукLohanovskyi Kostiantyn M., Talko Victoria V., Доктор медичних наук Registration Date 13-01-2020 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2 Object of study - neuroendocrine effects in the body of prenatal irradiated I-131 64 Wistar rats. The state of cognitive functioning and emotional-behavioral sphere and endocrine system in 73 people irradiated prenatally as a result of the Chernobyl accident and 54 irradiated persons. Objective: To determine distant effects in the postnatal period in the nervous and endocrine systems of prenatal irradiated I-131 rats at different gestational times. Assess the cognitive, emotional, behavioral and endocrine disorders in the victims who were exposed during the prenatal period following the Chornobyl disaster. Methods of experimental research: behavioral, enzyme-linked immunosorbent, biochemical, morphological, statistical. Methods of clinical research: neuropsychiatric, neuro and psychometric, neuropsychological, neurophysiological, statistical, dosimetric. Results. The peculiarities of neuroendocrine effects in irradiated in utero I-131 rats due to the receipt of radionuclide at different gestational times were established: behavioral reactions, morphofunctional changes in brain and thyroid structures, metabolic, neuroimmune disorders. The prenatal exposure showed a tendency to increase the frequency of neurocognitive deficits and emotional and behavioral disorders. Neurological deficits are mainly caused by stem and cerebellar symptoms as well as cerebral (intellectual) disorders. Decreased total and verbal IQ, as well as the disharmony of the development of intelligence by reducing verbal IQ was found. A probable diffuse decrease in the absolute and relative spectral power of the kEEG theta band was found in proportion to the increase in the in utero irradiation dose. Significant correlation was obtained between the decrease in the absolute spectral power of the kEEG range and the increase in doses of embryo and fetal irradiation and equivalent doses of thyroid gland in utero. Product Description popup.authors Antypchuk Kateryna Yu. Atamaniuk Natalia P. Afanasiev Dmytro Ye. Gresko Maryna V. Dmytriyeva Inna R. Kreynis Georgiy Yu. Kuts Kostiantyn V. Lavrenchuk Galyna Yu. Loganovska Tetiana K. Malyshevska Yevgheniya M. Masiuk Sergiy V. Perchuk Iryna V. Pleskach Oksana Ya. Chernyshov Andriy V. popup.nrat_date 2020-04-02 Close