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Information × Registration Number 0220U102212, 0117U000481 , R & D reports Title Experimental study of long-term neuroendocrine disorders caused by prenatal influence of endocrine disruptors with antiandrogenic or estrogenic activity. popup.stage_title Head Reznikov Oleksandr H., Доктор медичних наук Registration Date 11-03-2020 Organization State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine" popup.description2  Object of investigation: neuroendocrine regulation of reproduction and adaptation systems. Aim of investigation is the experimental study of neuroendocrine regulation of reproduction and adaptation systems. Methods: general biological, biochemical, hormonal, morphological, statistical. Results: In young (6 and 10 months) offspring of male rats whose mothers were injected with dibutyl phthalate (DBP) at the threshold for teratogenicity dose (100 mg / kg) during the critical period of sexual differentiation of the brain - in the last week of pregnancy, hyperandrogenic state was revealed - and copulatory sexual behavior and a twofold increase in plasma testosterone levels against functional activation of Leydig cells. Subsequently, there was an accelerated aging of the reproductive system due to testosterone deficiency compared to control. At the same time, in young and aging animals (18 months) in the glands, the state of oxidative stress developed, as evidenced by the increase in the content of lipid peroxidation products. The results of a neuromorphological study of the adult male's sex-dimorphic medial preoptic brain nucleus (IPF) indicate a tension in the function of neurocytes. Product Description popup.authors Lymareva Anna A Polyakova Lubov I Sachynska Olga V Falyush Oksana A popup.nrat_date 2020-04-01 Close