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Information × Registration Number 0220U102617, 0119U000578 , R & D reports Title Optimize the comprehensive treatment of children with central nervous system embryonic tumors, tumors of the family of Yuinga sarcoma / primitive neuroectodermal tumors and high-risk neuroblastomas popup.stage_title Head Klymniuk Hryhorii I, Registration Date 10-04-2020 Organization National Cancer Institute popup.description2 Object of study: results of treatment of 262 children with CNS embryonic tumors, Ewing / PNE (CS / PNE) sarcoma tumors and high-risk neuroblastomas. As a result of the research, the factors of unfavorable prognosis for such forms of solid malignancies in children as embryonic tumors of the central nervous system and neuroblastoma were investigated. Clinical, morphological and molecular-genetic methods were used. Factors in the unfavorable prognosis of CNS embryonic tumors (criteria for intensification of treatment at the initial stages) are nuclear expression of β-catenin, the presence of N-myc and C-myc gene amplification. The status of tumor DNA ploidy in neuroblastoma and the presence of N-myc amplification may serve as additional criteria in predicting disease progression and stratification of patients at risk. In 67% of children with neuroblastoma over 18 months of age and in 25% of patients with 18 months of age with diploid tumor DNA variability and lack of N-myc gene amplification, inadequate response to treatment and adverse disease was observed. The overall survival of N-myc negative patients was 53.8%, N-myc positive - 37.1%. The introduction of double (tandem) high-dose polychemotherapy with autologous peripheral blood stem cell transplantation statistically significantly increased the survival rate of children with medulloblastoma by 33.3%. The overall survival of transplanted children with CNS embryonic tumors was 76.9%. The use of extracorporeally irradiated autostones is one of the promising methods of surgical treatment of bone sarcoma in children, which allows to expand the possibility of performing organ-saving operations, enables the establishment of oncoendoprosthesis at a large length of resection, at some locations allows for organ-saving operative preservation.  Product Description popup.authors Velymchanytsya Mykhaylo V Klymniuk Hryhorii I Prykhodʹko Iryna O Shaida Elen V popup.nrat_date 2020-07-03 Close