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Information × Registration Number 0220U103077, 0120U101233 , R & D reports Title Investigation of molecular and cell mechanisms of immune mediated disorders of female reproductive system and corrective influence of nanoparticles of metals. popup.stage_title Head Yanchii Roman I, Доктор біологічних наук Registration Date 27-07-2020 Organization Bogomolets Institute of Physiology popup.description2  The effect of NO, nanoparticles of zero valent iron and glutathione on mouse ovarian cells under conditions of immuno-mediated pathologies was studied. It was found that NO is involved in the effect of nanoparticles zero valent iron on the process of meiotic maturation of oocytes and the viability of cells of the follicular environment of oocytes in the conditions of experimental immune damage. It is shown that the introduction of glutathione under conditions of experimental systemic autoimmune damage leads to an improvement in the ability of oocytes to meiotic maturation and increase the viability of follicular cells. Pathogenetic mechanisms under conditions of endotoxemia modeling have been studied. The protective effect of Ge citrate application on ovarian granular cells and thymus and lymph node cells is shown. It was found that the inhibition of PARP-1 under endotoxemia was accompanied by a decrease in the functional activity of inflammatory effector cells. Product Description popup.authors Blashkiv Taras V. Voznesenska Tetiana U. Grushka Nataliya G. Kaleynikova Oksana M. Kondratska Olena Olena А. Litvinenko Alina P. Pilkevych Natalia O. Pavlovich Svitlana I. Portnichenko Vladimir I. Sribna Valentyna O. Stupchuk Maria S. popup.nrat_date 2020-10-01 Close