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Information × Registration Number 0221U100821, 0120U104960 , R & D reports Title Myogenic mechanisms of urinary bladder mechanical sensitivity in norm and type 2 diabetes. popup.stage_title Head Shuba Yaroslav М., Доктор біологічних наук Registration Date 09-01-2021 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  The obtained results show that: 1) the hyperglycemiaparameters of the created model of experimental diabetes in rats correspond to type 2 diabetes; 2) urodynamic parameters in diabetic animals in relation to controls undergo significant changes; 3) a decrease in the volume to pressure ratio in animals with diabetes compared with the controls indicates a decrease in the mechanical sensitivity of the bladder wall due to dysfunction of the mechanisms responsible for such sensitivity in diabetes; 4) the expression of calcium-permeable mechanoactivated channels of the inward current - PIEZO1, PIEZO2 and TRPV4 in diabetes decreases slightly in the detrusor, but increases in the urothelium, while the expression of the potassium-permeableTREK-1 (KCNK2) channel on the contrary - decreases in the urothelium and increases in the detrusor; 5) data on the expression indicate an increase in the inhibitory effects on DSM and the prevalence of relaxation over contraction in diabetes. Product Description popup.authors Yelyashov Semen I. Kravchuk Lev I. Sotkis Anna V. Stolyar Lyubov A. Filipov Igor B. Sharopov Bizhan R. popup.nrat_date 2021-03-17 Close