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Information × Registration Number 0221U102325, 0118U003301 , R & D reports Title Biochemical mechanisms of neuroplasticity in conditions of hyperglycemia and violation of circadian rhythms in different periods of ontogenesis popup.stage_title Head Kyrychenko Svitlana V, Registration Date 01-02-2021 Organization Oles Honchar Dnipro National University popup.description2 The objects of research are neuroplasticity of the central and peripheral nervous system. The purpose is a comprehensive study of biochemical mechanisms of neuroplasticity in hyperglycemia and circadian rhythms, the study of the ratio of adhesive proteins, intermediate filaments of neurons, astrocytes and components of the intercellular matrix at different stages of ontogenesis and the correlation of changes in these relationships mammals; determination of the neuroprotective effect of natural antioxidants. Research methods: biochemical, immunochemical, immunohistological, physiological, statistical. The obtained results are used in the process of creating the newest scientific bases, methods and principles of optimization of neuroplasticity processes under the conditions of hyperglycemia development and / or circadian rhythm disturbances. For the first time, studies of chronic hyperglycemia and circadian arrhythmias, experimental studies, which analyzed the complex characteristics of behavioral responses of animals, and biochemical and molecular response of neurons, astrocytes and components of oxidative stress in different parts of the brain responsible for cognitive functions; detection of biochemical indicators of damage to the peripheral nervous system (liver, heart, kidneys) connections between them under the influence of hyperglycemia and circadian rhythm disorders under conditions of ontogenesis. The effect of natural antioxidants (melatonin, vitamin E, curcumin) has been studied. Scientific results can be used as a basis for a comprehensive assessment of the nervous system in the development of pathological conditions by determining in the serum indicators of nervous system damage in the development of diabetes, which has indisputable and sound scientific and practical feasibility and is an important area of biochemical research. Improving the quality of life and health of the population, the effectiveness of diagnosis and treatment of patients. Product Description popup.authors Blaschuk Olesya P Vasileha Nika S Gavrylyuk Victoria G Gorilla Maryna V Dovban Olena O Dyomshina Olga O Kovalchuk Yulіia P Kuzmenko Daria S Kutinova Olexandra V Loktionova Anna V Muravyova Diana V Murdasov Eugene V Pavlenko Anna Yu Pertsev Nikita S Rezyapov Artur Yu Skorik Olena D Sokolova Iryna Ye Ushakova Galyna O. Khomenko Olena M Tsurkan Olexander M Che Kateryna V Scherbina Tetiana V. popup.nrat_date 2021-02-01 Close