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Information × Registration Number 0221U102670, 0118U004053 , R & D reports Title Determination of individual features of immune response immune responses to vaccination for the personification of vaccine prophylaxis in preschool children popup.stage_title Head Volyanskiy Andriy Yu, Registration Date 08-02-2021 Organization State Institution "I. Mechnikov Institute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine" popup.description2  Object of the study: peripheral blood and serum 174 children aged 1 to 10 years who were treated and vaccinated in the children's medical center "Your child". As a control group, 40 children of the appropriate age were selected, for the duration of the examination they did not carry the viruses of the Herpesviridae family. All children were vaccinated according to age. Objective: to determine the specific features of the formation of a specific immune response in persons of different age groups of patients with chronic recurrent herpesvirus infection when using vaccine preparations of various types. Methods of research: immunological, serological, clinical, statistical. Among the children examined, the clinical signs of chronic viral infections (lymphadenopathy, granularity of the posterior pharynx) were more often detected than in the control group. In children with chronic herpesvirus infection (CHVI), infection with two or more viruses of the Herpesviridae family exceeded 90%. Antibodies to four representatives of herpesviruses had more than 52% of the children examined. Children with CHVI have an imbalance in the humoral immune response to vaccination. A significant percentage of children with CHVI have unbalanced specific humoral immunity (hypo- and hyperproduction of specific antibodies) to infections that are inoculated. The results of our studies indicate that the overall total response of the T, B and phagocytic immunity to vaccination in children with CHVI in whom no prolonged immunity is observed is significantly lower than in the control group in which protective antibody titers are formed. A certain imbalance and a decrease in the relative number of different populations of memory T cells in response to vaccination with different types of vaccines in children with CHVI compared with healthy children indicates a violation in the mechanisms of formation of cellular immune memory. A method for determining the functional activity of lymphocytes on the bio Product Description popup.authors Volyansky Andrey Yu Davydenko Maryna B Kashpur Nataliia V. Klysa Olena O Klysa Tetiana L Kuchma Irina Yu. Kuchma Maxym V Navet Tetiana I Peremot Svitlana D Smilianska Maja V Stepnova Julia B Khodak Larysa A Chursin Volodymir V popup.nrat_date 2021-02-08 Close