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Information × Registration Number 0221U103314, 0118U001276 , R & D reports Title Investigation of the mechanisms of the central nervous system in conditions of extreme factors, including against the background of intoxication with heavy metals popup.stage_title Head Dovhal Maryna A, Registration Date 18-02-2021 Organization State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine" popup.description2  In the course of the work it is planned to establish the definition of the peculiarities of the mechanisms of central nervous system disturbance under the action of extreme factors after the action of air shock wave factor and lead acetate. the problem of mechanisms of development of functional and morphological changes of the central nervous system under the action of extreme factors after the action of air shock wave factor and lead acetate is solved in the work. The study found a general excitation of the CNS of rats with SCI with an increased level of anxiety in the acute period, as evidenced by an increase in GRA by 25% (p <0.05) and BPA by 44% (p <0.05), with subsequent suppression of emotional condition and approximate research activity in the early period of mild SCI, as evidenced by a decrease in the number of examined minks by 65% ​​(p <0.05) and the number of grooming acts by 48% (p <0.05. As well as violations of approximate spatial memory. It is shown that the dynamics of pathomorphological changes of the brain in the studied period had characteristic features in the form of diffuse microhemorrhages in the hippocampus in the acute period of injury, diffuse areas of perivascular and pericellular edema in the early posttraumatic period and paretically dilated capillaries in the capillaries. -3rd week of the post-traumatic period Product Description popup.authors Klopotskyi Heorhij A Kozlova Yuliia V Koldunov Victor V Khmel' Stanislav I Khudiakov Olexandr Ye popup.nrat_date 2021-02-18 Close