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Information × Registration Number 0221U103666, 0118U005173 , R & D reports Title Development and optimization of biosensor monitoring system of neurotransmitters for express diagnostics and control of the effectiveness of treatment of neuropathology. Section 2. Development, optimization and experimental exploitation of biosensor smart systems for monitoring neurotransmitters popup.stage_title Head Soldatkin Oleksandr O., Доктор біологічних наук Registration Date 23-02-2021 Organization Institute of Molecular Biology and Genetics of NAS of Ukraine popup.description2  In the course of the work, a multisensory array was developed for the simultaneous determination of glutamate, lactate, pyruvate and choline. The effect of solution parameters (pH, ionic strength and buffer capacity) on monobiosensor responses was investigated. We analyzed the prospects of operation of all monobiosensors in the same conditions as part of a single array of sensors. The presence of cross-exposure of substrates of all used enzymatic systems was investigated. It is shown that the array was characterized by high selectivity for possible interferences. The created array of biosensors has a high reproducibility of responses and storage stability. The main analytical characteristics of the developed monobiosensors, such as sensitivity, response time, were also investigated. biosensors, linear range and limit of substrate determination. The developed array of biosensors based on the same transducers and similar conditions of enzyme immobilization is promising for mass production. Product Description popup.authors Kucherenko Ivan S. Kucherenko Daria Yu. Mruga Daryna O. Shkotova Lyudmyla V. popup.nrat_date 2021-02-23 Close