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Information × Registration Number 0221U103761, 0118U003031 , R & D reports Title Determine the mechanisms of the formation of cardiac output in hypertrophy and dilatation of the left ventricle of the heart popup.stage_title Head Zakharova Valentyna P, Registration Date 25-02-2021 Organization State Institution "National Institute of Cardiovascular Surgery named after MM Amosov of the National Academy of Medical Sciences of Ukraine" popup.description2 The subject of the study is the myocardium of the left ventricle of the heart in pathologies that are accompanied by hypertrophy and dilatation of the left ventricle. The purpose of the work is to investigate the morphofunctional foundations of cardiac output formation in myocardial hypertrophy and left ventricular dilatation in various heart pathologies based on the modern theory of myocardial structure. Research methods - morphological (light-optical microscopy, electron microscopy, morphometric research), echocardiography (traditional and speckle tracking), statistical. Morphofunctional characteristics of cardiomyocytes (CMC) in diffuse and/or local systolic and diastolic overload of left ventricular myocardium, mechanisms of adaptation, as well as criteria of maladaptation were studied. It has been proven that CMC hypertrophy is a compensatory response to increasing their function. It has been shown that an increase in systolic load on CMCs causes an expansion of their transverse dimensions due to an increase in the number of myofibrils. It has been found that systolic (transverse) myocardial hypertrophy can be diffuse with increased resistance to cardiac output and local in various types of fibrosis and increased angularity of muscle bundles. It was found that diastolic (longitudinal) myocardial hypertrophy develops in response to overload of the heart cavities with blood volume and manifests itself by lengthening the CMC due to an increase in the number of sarcomers. Decompensation of longitudinal CMC hypertrophy is manifested by desynchronization of their contractions due to myofibril ruptures, as well as myocytolysis due to capillary blood flow deficiency (capillary length does not correspond to CMC length). Longitudinal myocardial hypertrophy in NdMK is accompanied by an increase in semi-long displacement, deformation and rotation in most segments of the basal and middle LSh. In GKMP, there is a diffuse defeat of CMC by various factors, which leads to their Product Description popup.authors Dorofeeva Svitlana I Zakharova Valentina P Rudenko Olena V Trembovets'ka Olena M popup.nrat_date 2021-02-25 Close