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Information × Registration Number 0221U106647, 0118U006190 , R & D reports Title Intellectual chemosensory systems for medical diagnostics of therapeutically important amino acids and their derivatives based on calixarene-containing compounds. Section 2. Molecular design and synthesis of highly selective calixarene receptors forming supramolecular complexes with amino acids and their derivatives popup.stage_title Head Kalchenko Vitalii I., Доктор хімічних наук Registration Date 16-12-2021 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2  In order to create enantioselective sensors capable of distinguishing D and L forms of biologically important amino acids and their derivatives, the methods of the synthesis of new types of enantioselective receptors based on inherently chiral calixarenes with asymmetrically substituted upper ring of the macrocycle were developed. Have been shown that 25-propyloxy-26,27-dibenzoyloxy-calix[4]arenes is a convenient precursor for the synthesis of inherently chiral derivatives. Convenient methods of regioselective functionalization of para-positions of the upper crown of the macrocycle of this compound have been developed. Diastereomeric derivatives of inherently chiral calix[4]arenes were synthesized and their separation into optically pure forms was performed. The structure of the obtained compounds was studied by NMR spectroscopy and X-ray diffraction analysis and the absolute stereochemical configuration was determined. Product Description popup.authors Yesypenko Oleksandr Adolfovich Atamas Lyudmila Ivanivna Boiko Yuriy Sergijovich Vyshnevskiy Sergiy G. Dovgopyata Lidiya Soloveyivna Drapailo Andriy Bogdanovich Kalchenko Vitaly Ivanovich Rodik Roman V Silenko Oleg M. Selihova Anna I Trybrat Olexandr O. Cherenok Sergiy Olexiyovich popup.nrat_date 2021-12-16 Close