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Information × Registration Number 0221U106667, 0120U103978 , R & D reports Title Design, synthesis and activity of calixarene derivatives as inhibitors of protein tyrosine phosphatases and other enzymes popup.stage_title Head Kalchenko Vitaly I., Доктор хімічних наук Registration Date 17-12-2021 Organization Institute of Organic Chemistry NAS of Ukraine popup.description2 The amphiphilic calixarenes with hydrophobic alkyl groups C8-C16 on the lower rim of the macrocycle and hydrophilic biophoric groups of anionic and cationic type (carboxylic, phosphonate, tetralkyammonium, imidazolium groups) on the upper rim were synthesized. The inhibitory ability of new amphiphilic calixarenes against protein tyrosine phosphatases RTP1B, TC-RTP, MEG1, MEG2 and VE-PTP was established. Based on the obtained kinetic data and the results of computer simulations, the relationship between the structure and activity of amphiphilic anionic inhibitors in vitro was established, and possible mechanisms of inhibition were proposed.   Product Description popup.authors Buldenko Vladyslav M. Vovk Andrii І. Kalchenko Vitalii I. Kobzar Oleksandr L. Selihova Anna I. Trybrat Oleksandr O. Cherenok Serhii O. Shulga Yuriy V. popup.nrat_date 2021-12-17 Close