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Information × Registration Number 0222U000078, 0121U114669 , R & D reports Title Dysfunction of the blood-brain barrier and the development of epileptic seizures: the role of serum proteins popup.stage_title Head Savotchenko Alina V., Кандидат біологічних наук Registration Date 02-01-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Blood-brain barrier dysfunction (BBB) is an important factor to the development of epilepsy and its behavioral cormobidities. Disruption of its integrity is accompanied by the ingress of blood components, including thrombin, into the cerebrospinal fluid. The effect of thrombin is mediated mainly through its major receptor, protease-activated receptors 1 (PAR1). Using lithium-pilocarpine model of seizures, we show that downregulation of PAR1 activity reduces anxiety and aggressive behavior in epileptic rats, and restores distinct forms of hippocampal synaptic plasticity in experimental model of temporal-lobe epilepsy. Taken together, our data suggest that PAR1-signaling promotes the development of acquired epilepsy. PAR1 may be a new potential target for the treatment of this disorder and associated behavioral pathologies. Product Description popup.authors Dryn Darіya O. Mel’nyk Maria I popup.nrat_date 2022-03-09 Close