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Information × Registration Number 0222U000143, 0119U002135 , R & D reports Title Determination of the functional role of candidate gene single-nucleotide polymorphisms, which are relevant for type 2 diabetes mellitus development, in the implementation of hormonal-metabolic effects of pharmacological agents popup.stage_title Head Registration Date 03-01-2022 Organization State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine” popup.description2 Objects of research - patients with type 2 diabetes mellitus, single-nucleotide polymorphisms. Aim - Detection of the impact for potentially pathogenically significant single-nucleotide polymorphisms of candidate genes relating to the development of obesity and type 2 diabetes mellitus on the implementation of hormonal-metabolic effects of pharmacological agents. Methods - pathophysiological, clinical, genetic, biochemical, molecular biological, instrumental and statistical. The study of functional significance of single-nucleotide polymorphisms of the leptin gene LEP -2548G/A (rs7799039), leptin receptor gene LEPR 223Q/R (rs1137101), interleukin-6 gene IL6 -174G/С (rs1800795) and protein p53 gene ТР53 P72RC/G (rs1042522) in the East-Ukrainian population of type 2 diabetic patients was carried out. The impact of polymorphic variants of the candidate genes on the hormonal-metabolic effects of omega-3 polyunsaturated fatty acids was determined, and more reactive were the recessive genotype for LEP -2548G/A and dominant alleles for LEPR 223Q/R and IL6 -174G/С. The influence of investigated polymorphisms on the risk of micro- and macrovascular complications in patients with type 2 diabetes mellitus was evaluated. It has been found that the heterozygous genotype for LEP -2548 G/A increases the risk of cardiac failure development in women, and the G-allele increases the risk of heart failure and coronary heart disease in men, the presence of heterozygous genotype by polymorphism LEPR 223Q/R (A/G) is associated with a lower risk of heart failure development in men, and the minor allele by polymorphism -174 G/C of IL6 gene increases the risk of ischemic heart disease and neuropathy development in type 2 diabetic patients of East-Ukrainian population of both sexes. Product Description popup.authors Karatchentcev Yuri Ivanovich Poltorak Viktoriia V popup.nrat_date 2022-03-09 Close