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Information × Registration Number 0222U000304, 0120U102510 , R & D reports Title To optimize the diagnosis and to develop methods for non-specific prevention of community-acquired pneumonia caused by coronaviruses or their combination with bacterial pathogens popup.stage_title Head Dziublyk Oleksandr Ya., Доктор медичних наук Registration Date 05-01-2022 Organization State organization "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National academy of medical sciences of Ukraine" popup.description2 The object of the study - patients with community-acquired pneumonia (CAP) caused by coronaviruses, strains of viruses and bacteria. The aim of the work is to improve the etiological and clinical-radiological diagnosis and methods of non-specific prevention of CAP caused by coronaviruses or their combination with bacterial pathogens. Methods - clinical and radiological, microbiological, statistical. It was developed an algorithm for diagnosing CAP caused by coronaviruses or their combination with bacterial pathogens, which includes a set of clinical, laboratory and instrumental studies, the volume of which is determined by the severity of the emergency. Also it was developed the scheme of microbiological identification of the main pathogens of CAP, which involves the use of modern diagnostic rapid tests in combination with molecular biological (polymerase chain reaction) and classical bacteriological diagnostics. The possibility of using digital image processing of computed tomography of the lungs using the neural network U-Net, which can be used in the further development of COVID-19 diagnostic systems. It was found that aminocaproic acid (ACA) in the model of IBV in sensitive culture of cells in vitro showed low toxicity, which was decreasing over time. While using the prophylactic-therapeutic and therapeutic regimen of infection, effective inhibition of virus reproduction was found in 24 and 48 h after the use of ACC in diapason of non-toxic concentration, which indicates the antiviral activity of the drug in the early stages of coronavirus reproduction. Preventive measures for COVID-19 close contacts have been developed, consisting in the appointment in addition to general anti-epidemic measures of eye drops and inhalations with a solution of decamethoxine, as well as quartz tube endonasally, which are carried out during the first 10 days portable devices for individual use to prevent infection of others. Sphere of application - pulmonology. Product Description popup.authors Bororova Olena L Velychko Olga O Gumenuk Mykola I Denysova Olha V Dziublyk Iryna V Kapitan Heorhiy B Lynnyk Mykola I Mukhin Oleksandr O Sukhin Rostyslav Ye Trochymenko Olena P Yudina Liudmyla Volodymyrivna Yakovenko Oleg Kostyantynovych Iachnyk Vitalii A popup.nrat_date 2022-03-09 Close