Registration Number
0222U000515,
0120U104096
, R & D reports
Title
Glutamate/GABA signalling in bidirectional Gut-Brain communication system: a focus on harmful effects of air pollution carbon-containing nanoparticles
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Head
Borysova Tetyana O., Доктор біологічних наук
Registration Date
12-01-2022
Organization
Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine
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It was shown that the PM of smoke from the combustion of different types of wood differently affects the key characteristics of glutamate and GABAergic neurotransmission, ROS generation, the lipid order of the membranes of rat brain nerve terminals. The most neurotoxic was PM smoke from burning poplar, which can cause neurological consequences due to imbalance of excitation and inhibition in the central nervous system. It has been demonstrated the possibility of ion-conducting structures formation in bilayer lipid membrane under the action of smoke PM preparations and carbon-containing nanoparticles synthesized from organic compounds. The increase in transmembrane current caused by nanoparticles correlates with impaired transport of excitatory and inhibitory neurotransmitters in nerve terminals. Infrared and Raman spectra of smoke samples obtained from the combustion of different types of wood, grass and smoke of anthropogenic origin from the combustion of medical masks were obtained. Molecular groups on their surface have been identified that can be used in environmental monitoring. The influence of PM smoke preparations from wood mixture combustion and plastic combustion on ROS generation and key characteristics of glutamate and GABAergic neurotransmission were compared. It was shown for the first time that the initial rate of L-[14C]glutamate uptake did not change by PM of gasoline and diesel engine exhausts, but the initial rate of [3H]GABA uptake by nerve terminals increased by the action of gasoline engine exhaust. Smoke nanoparticles from plastic combustion reduced the adsorption and permeability of L-[14C] glutamate in intestine tissue.
Product Description
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Dudarenko Marina Volodymyrivna
Paliienko Konstantin Olegovich
Panas Ihor Dankovych
Rudenko Roman Mykolayovych
Hodorovska Irina О
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2022-03-09
