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Information × Registration Number 0222U000527, 0119U003661 , R & D reports Title The study of the quality of the donated blood erythrocytes during hypothermic storage in an additional nanotechnologically modernized solution. popup.stage_title Head Kalynychenko Tetiana Oleksiivna, Доктор медичних наук Registration Date 12-01-2022 Organization State Institution "Institute of Hematology and Transfusiology NAMS Ukraine" popup.description2  Object: red blood cells from canned blood from preserved donor blood that are intended for component transfusion therapy. Methods: cytological; biochemical; immunohematological, statistical. The quality of erythrocyte-containing components (ECCs) of donor blood during their storage in standard conditions of hypothermia (for 21-42 days at a temperature of 2-6 °C, and with CPDA-1, CPD, CPD + SAGM preservative solutions) has been studied. Dynamic changes in such parameters as hemolysis, erythrocyte membrane stability, the functional reserve of antioxidant enzymes, as well as activation levels of lipid peroxidation processes with gradual acidification of their environment have been established. It is confirmed that the central role in the genesis of pathophysiological changes that occur in erythrocytes during ECCs storage, belongs to the oxidation processes activation, as well as their products accumulation. Positive effects of nano modified with standardized biocompatible nanoparticles of magnetite 0.9% NaCl solution on the stability of red blood cells when it is used as an additional resuspending solution for the ECCs have been demonstrated. Medical and social effect. Medicine. Product Description popup.authors Anoshina Militina Yu Bilousov Andrii M Bortnik Hanna A Kalynychenko Tetiana Oleksiivna Liubych Valentyna V Malygon Olena I Pavliuk Raisa P Parubets Lidiia I Tymoshenko Uliana Vasylivna Iavorskyi Vadym Vasyliovich Yahovdik Maryna V popup.nrat_date 2022-03-09 Close