Search academic texts

Information × Registration Number 0222U000680, 0119U100640 , R & D reports Title The study of pathogenetic peculiarities of the development and progression of coronary heart disease in clean-up workers after Chornobyl accident over a 35-year period after irradiation exposure popup.stage_title Head Bilyi David O., Доктор медичних наукBazyka Dymytriy A., Доктор медичних наук Registration Date 14-01-2022 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2 Object of research is indicators of structural and functional state of the myocardium and relative telomere length (RTL) in 514 clean-up workers (CW) of the Chernobyl accident and 199 non-irradiated men – control group (CG) that were examined. The goal was to determine the impact of radiation and non-radiation risk factors on the development and course of coronary heart disease (CHD) in CW of the Chernobyl accident and to assess the role of telomere length as a pathogenetic marker of coronary atherosclerosis. Factors that determined the risk of CHD onset were the fact of participation in emergency work (PEW), age at the time of the accident and cholesterol level. The development of myocardial infarction depended on PEW and the presence of type 2 diabetes mellitus, which preceded the onset of CHD. This suggests that radiation exposure may be considered a risk factor for CHD. According to the analysis of left ventricle (LV) systolic and diastolic function, it was found that LV volumes and their indices were significantly higher in CW and CG with stenotic coronary sclerosis (SCS) compared with patients without SCS. In 48.8–50.2% of patients with SCS, both CW and CG it was revealed a violation of LV geometry in the form of eccentric LV hypertrophy (LVH), while 39.1–45.7% of CW and CG patients without SCS showed the concentric LVH. In patients with SCS of both groups, the relative telomere length (RTL) did not significantly differ. In CW with normal body weight, in contrast to obese people, telomeres were significantly shorter than in CG, which can be attributed to the radiation exposure of 30-35 years ago. Cluster analysis showed that in patients with higher LV average sizes and volumes, myocardial mass and its index, smaller ejection fraction and relative LV wall thickness telomeres were shorter – (10 ± 1.7) against (14.3 ± 2.0) (p = 0.000). Eccentric hypertrophy was significantly more common in them (87.4% vs. 42.6%, p <0.001). Product Description popup.authors Ilienko Iryna Mykolaivna Biliy David O Bazyka Dymytrii A Bazyka Olexander D Gabulavichene Zhanna Mikhailyvna Kovaliov Olexander S Kruglova Veronika O Kursina Natalia V Lyaskivska Olena Viktorivna Makarevich Оlena M Nastina Оlena M Sadova Svitlana V Sydorenko Gennagyi V popup.nrat_date 2022-03-09 Close