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Information × Registration Number 0222U000714, 0119U101455 , R & D reports Title Ion and membrane mechanisms of regulation of calcium homeostasis and myometrial contraction activity at different stages of pregnancy popup.stage_title Head Kosterin Serhii O., Доктор біологічних наук Registration Date 18-01-2022 Organization Department for special training National academy of science of Ukraine at Kiev University popup.description2  Using in vitro tensiometry of the isolated myometrium strips TRPV4 agonists and antagonists were shown to develop different effects in rat and human tissues in normal and pathophysiological condition, in the myometrium response to oxytocin TRPV4 play a role of the limiting factor. The research have found that the contractile response of the myometrium varies depending on the degree of its mechanical stretching, and the action of oxytocin and TRPC4 ion channel agonists differs from that without mechanical stress. In this research new evidences about mechano-sensitive properties of TRPC4 were obtained. A perspective to use liposomes with incorporated agonists of maxi-K channels as the inhibitors of uterine contractions was shown in experiments with quercetin and nitric oxide. Water-soluble pristine C60 fullerene appeared to affect the spontaneous and oxytocin-stimulated rat uterus in the late gestation. The study developed an algorithm for quantitative analysis of uterine contractions (6 different parameters). Product Description popup.authors Babich Lidiia G. Veklich Tetiana Oleksiivna Danylovych Hanna Victorivna Danylovych Yurii V. Kosterin Sergiy О. Soroka Vasyl M. Shlikov Sergiy G. popup.nrat_date 2022-03-09 Close