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Information × Registration Number 0222U000807, 0117U001729 , R & D reports Title Experimental estimation of the effectiveness of application and biocompatibility testing algorithm of domestic implantation materials, based on calcium phosphates, for the restoration of the function of the musculoskeletal system in the malignant process. popup.stage_title Head Lukianova Nataliia Yu., Доктор біологічних наук Registration Date 18-01-2022 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2 During the implementation of the scientific and technical project on the clinical material ex vivo the peculiarities of interaction of domestic implant materials based on calcium phosphates with non-malignant cells of patients with breast and prostate cancer with metastatic bone lesions were analyzed. The results of studies of molecular biological characteristics indicate that biomine has no toxic effects and does not activate the proliferation of peripheral blood and bone marrow cells of patients with advanced breast and prostate cancer. Based on the study of the expression profile of oncogenic microRNAs (-126, -146a, -155 and -223), as well as the assessment of DNA damage using comet assay and micronucleus test, it was determined that biomine does not cause epigenetic disorders and genotoxic effects in peripheral blood lymphocytes patients with breast and prostate cancer with metastatic bone lesions. An algorithm for testing the biocompatibility of domestic implant materials based on calcium phosphates to assess the effectiveness of recovery of musculoskeletal function in malignant processes was developed. The algorithm is based on the identification of genotoxic effects and epigenetic disruptions in peripheral blood lymphocytes of patients with metastatic breast and prostate cancer after exposure to the material. Product Description popup.authors Borikun Tetiana V. Zadvornyi Taras V. Lykhova Olexandra O. Chekhun Vasyl F. popup.nrat_date 2022-03-09 Close