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Information × Registration Number 0222U000837, 0121U110868 , R & D reports Title Plasmon hybrid nanosystems "metal-polymer-fluorophore" with enhanced optical response for photonics and biomedical applications popup.stage_title Head Yeshchenko Oleh А., Доктор фізико-математичних наук Registration Date 19-01-2022 Organization Taras Shevchenko National University of Kyiv popup.description2  Object of research: hybrid nanosystems based on polymer matrices, metal nanoparticles (NPs) and fluorophores-dyes; thermosensitive polymers; photosensitive polymers. Subject of research: processes of interaction and binding of components of hybrid nanosystems; the effect of plasmon amplification on the optical properties and biological activity of hybrid nanosystems; thermo-induced phase transitions in hybrid nanosystems; electronic processes in photosensitive polymers based on aurons. Purpose: synthesis of nanosystems "metal-heat-sensitive polymer-dye" for heat-sensitive optical switches and fluorescent labels, the establishment of physical mechanisms of temperature influence on their optical properties; synthesis of nanosystems "metal-polymer-sensitizer", study of their effectiveness for photodynamic therapy; study of nonlinear optical properties of photosensitive polymers based on aurons. Research methods: transmission electron microscopy (SEM), dynamic light scattering (DRS), absorption spectroscopy and photoluminescence (PL), measurement of the second and third harmonics, numerical computer calculations. Results and novelty: Triple hybrid nanosystem "HP1476 dye / thermosensitive polymer D-g-PNIPAM / LF Au" was synthesized. Fully reversible photoluminescence amplification-quenching of the HP1476 / D-g-PNIPAM / LF Au nanosystem 1.5 times was detected during the heating-cooling cycle in the temperature range 25 - 47 0С, containing the temperature point of the phase LCST transition in the polymer. The use of this thermal effect in thermosensitive fluorescent optical switches or labels and for intracellular fluorescent thermometry has been proposed. An in vitro study has shown that the use of the D-g-PNIPAM / LF Au / Ce6 nanosystem prevents the aggregation of the photosensitizer and therefore can provide targeted drug delivery to tumor cells. Product Description popup.authors Virych Pavlo A. Kuziv Yuliya I. Kutsevol Nataliia Volodymyrivna Smokal Vitalii O. Tomchuk Anastasia V. Khort Pavlo S. popup.nrat_date 2022-03-09 Close