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Information × Registration Number 0222U001016, 0121U112150 , R & D reports Title Modulation of nuclear receptors target genes expression, activated by peroxisome proliferators in heart failure experimental therapy popup.stage_title Head Shysh Anzhela M., Кандидат біологічних наук Registration Date 23-01-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  As a result it was determined the expression of genes that are regulating pathological processes in miocardium of animals with the diabetes mellitus and cardiac deficiency development, and it was shown the modulating influence of omega-3 PUFAs and quercetin on their levels. In rats of both lines the expression of the gene FATP and mRNA of IL-1ra was shown to increase in the heart when PPAR-receptors were activated, in particular the most expressed effect was in old rats. Under conditions of arterial hypertension, it was shown the increase of lncRNA expression influenced by modulation of PPAR-target genes expression. Product Description popup.authors Gorlova Anastasia P. Zhukovska Anna S. Kozlovskaya Maria G. Kotlyarova Anna Borysivna Laguta Tetyana I. Lapikova-Briginska Tetyana Yu. Maksymchuk Oksana V. Morgachev Roman O. Portnichenko Heorhiy V. Strutynskyi Ruslan B. popup.nrat_date 2022-03-09 Close