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Information × Registration Number 0222U001160, 0119U000086 , R & D reports Title Study of the regenerative potential of cardiac-derived stem cells on the models of heart injury in mice popup.stage_title Head Butenko Hennadii M, Registration Date 24-01-2022 Organization Institute of genetic and regenerative medicine National Acad.Med.Sci. of Ukraine popup.description2 Protocols for obtaining cultures of myocardial progenitor cells from the heart of mice and humans were developed, their proliferative potential in dynamics and phenotype for the expression of specific markers were characterized. Progenitor cell cultures isolated from the myocardium of newborn mice have been shown to have better proliferative potential and contractile activity compared to cells isolated from adult animals. Cells from the atrial appendage differ in characteristics from cells from the ventricles. Troponin I expression was confirmed in cultures of myocardial cells with contractile activity. A minor CD117 population of cardiac stem cells was identified. Fibronectin and poly-D-lysine are necessary conditions for the formation of cardiospheres. The regenerative effects of mesenchymal stromal placental stromal cells on the myocardium were evaluated in a model of isoproterenol-induced cardiomyopathy.  Product Description popup.authors Kyryk Vitalii Mykhailovych Klymenko Pavlo P Kondratenko Kostyantin M Rybachuk Oksana А. Skybo Galyna G. Ustymenko Alina M Tsupykov Oleg M. Shmatko Galina A popup.nrat_date 2022-03-09 Close