Registration Number
0222U001222,
(0120U101649)
, R & D reports
Title
Synthesis, modification and study of the properties of 1,2,4-triazole derivatives for the purpose of antimicrobial drug production
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Розробка стратегії пошуку серед похідних 1,2,4-тріазол-3-тіону речовин з (антимікробною) проти-туберкульозною активністю. Прескринінгові та скринінгові дослідження синтезованих сполук для виявлення сполуки-кандидата для створення лікарського засобу.
Head
Panasenko Oleksandr I., Доктор фармацевтичних наук
Registration Date
25-01-2022
Organization
Zaporizhzhya State Medical University
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The aim of this work is to synthesize new biologically active compounds in a series of 1,2,4-triazole, to study their physicochemical and biological properties, to establish regularities of the connection between chemical structure and biological action, and to introduce into the practice of practice new effective agents based on derivatives 1 , 2,4-triazole with anti-tuberculosis activity.
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Object of study. Reactions of acylation, nucleophilic substitution, heterocyclization, hydrazinolysis in the synthesis of 1,2,4-triazole derivatives and products of their further modification as promising biologically active agents.
The aim of this work is the synthesis of new biologically active compounds in the series 1,2,4-triazole, study of their physicochemical and biological properties, establishing patterns of connection between chemical structure and biological action and introduction into medical practice of new effective drugs based on derivatives 1,2,4-triazole with antituberculosis activity.
Research methods. To create a biologically active substance, conventional methods of organic synthesis will be used, physicochemical methods, including elemental analysis, chromato-mass spectrometry, IR, 1H and 13C NMR spectroscopy, have been used to establish the peculiarities of the course of reactions, determine the purity and structure of synthesized compounds. . Methods of in silico, in vitro and in vivo screening of biological activity, statistical methods will be used to study the biological activity of synthesized compounds.
A combinatorial library of synthesized compounds derived from the 1,2,4-triazole heterocyclic system with targeted antibacterial activity with an appropriate synthesis strategy among 1,2,4-triazole-3-thione derivatives has been created. Potential leader compounds were isolated and the mechanism of action was investigated by molecular docking. Screening studies of 1,2,4-triazole-3-thione derivatives on antimicrobial and fungicidal activity were performed.
Product Description
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Al Khalaf Nataliia A.
Bihdan Oleksii A.
Hotsulia Andrii S.
Davydenko Pavlo O.
Donchenko Anastasiia O.
Volodymyr V. Zazharskyi
Karpenko Yurii V.
Karpun Yevhen O.
Lysianska Hanna P.
Polishchuk Nataliia M.
Samelyuk Yurii G.
Safonov Andrii A.
Shcherbyna Roman O.
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2022-03-09
