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Information × Registration Number 0222U001223, 0120U101650 , R & D reports Title Development of techniques for analysis and study of 1,2,4-triazole derivatives as promising active pharmaceutical ingredients using high performance liquid chromatography popup.stage_title Head Kaplaushenko Andrii H., Доктор фармацевтичних наук Registration Date 25-01-2022 Organization Zaporizhzhya State Medical University popup.description2 Object of research: morpholine 2-((4-(2-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetate and other 1,2,4-triazole derivatives. The purpose of the study: Creating scientific approaches to chromatography with mass spectrometry detection methods for establishing purity, molecular mass, structure, identification and quantification of a number of derivatives 1,2,4-triazole, development and validation of methods that allow control the content of these substances in intermediates, active pharmaceutical ingredients, drugs and biological liquids. Research methods: High performance liquid chromatography with diode array detection, mass spectrometry, thermodynamic method, pharmacokinetics method. Results and their novelty. The technique with use is developed liquid chromatography with mass spectrometric detection to determine active pharmaceutical ingredient of the drug "Thiometrizol" in plasma blood of rats. The substance of the drug "Thiometrizol" was studied. The optimal conditions of sample preparation in the study of derivatives are proposed 3-thio-1,2,4-triazole in pharmaceutical and biological samples. The metabolism of the active pharmaceutical ingredient of the drug has been established "Thiometrizol" in the blood plasma of rats [1]. A study was conducted pharmacokinetics of the active pharmaceutical ingredient of the drug "Thiometrizol" in the blood plasma of rats [2]. The homogeneity of the substance of the drug "Thiometryzol" was checked. A certified pharmacopoeia standard sample of morpholines 2-((4-(2-methoxyphenyl-5-(pyridin-4-yl) -4H-1,2,4-triazol-3-yl)thio)acetate has been developed potential drug "Thiometrizol" [3]. Conducted research of the thermodynamic parameters of morpholine 2 -((4-(2-methoxyphenyl)-4H-1,2,4-triazolyl)thio)acetate (API veterinary drug "Avesstim", which exhibits antioxidant, immunomodulatory, anti-inflammatory, hepatoprotective and detoxifying effects, normalizes metabolism. Product Description popup.authors Avramenko Antonina I. Buhaiova Vladlena V. Varynskyi Borys O. Vasiuk Svitlana O. Matviienko Liubov B. Pruhlo Yevhen S. Rudakova Olga O. Frolova Yuliia S. popup.nrat_date 2022-03-09 Close