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Information × Registration Number 0222U001473, 0119U000243 , R & D reports Title Synthesis, structure and reactivity of new N-acyl-1,4-benzoquinoneimines. New bioactive compounds and additives for technological liquids. popup.stage_title Head Avdeenko Anatoly P., Кандидат хімічних наук Registration Date 27-01-2022 Organization Donbass State Engineering Academy popup.description2 The object of the study is N-acyl-1,4-benzoquinone imines, derivatives of N-arylaminocarbonyl and N-carbamoyl-1,4-benzoquinone monoimines. The subject of the study is development of convenient and effective methods of synthesis of new derivatives in the result of reactions of N-acyl-1,4-benzoquinone monoimines with N- and C-nucleophiles, synthesis of new nitrogen- and oxygen-containing heterocycles compounds that are potential biologically active compounds and good additives to process fluids. Research methods are organic synthesis, X-ray diffraction analysis, NMR 1H spectroscopy, IR spectroscopy, quantum chemical calculations, elemental analysis. Preparative methods for the synthesis of new derivatives, based on N-acyl-1,4-benzoquinonymines with various substituents in the quinoid nucleus, as a result of their reactions with C- and N-nucleophiles have been developed. In particular, derivatives of benzofuran and pyrazole were obtained. Pyrazole derivatives have been synthesized by the interaction of 4-aminoantipyrine with 2,6-dialkyl derivatives of N-chloro-1,4-benzoquinone monoimine and with 2,5 (2,6)-dialkyl derivatives of 1,4-benzoquinone, which can show a wide range of biological activity. In particular, such compounds may have antimicrobial, antiviral, antitumor, antihistaminic effects, may be used as antidepressants, insecticides and fungicides. As a result of the interaction of N-aroyl-, N-benzylideneacetyl-, N-arylaminocarbonyl-1,4-benzoquinone monoimines with arylenamines based on acetylacetone and acetoacetic ester, the benzofuran derivatives were obtained. Derivatives of N-acyl-1,4-benzoquinone monoimines and products derived from their reactions with N- and C-nucleophiles have been found to have bactericidal activity against Mycobacterium luteum and Staphylococcus aureus. New compositions of technological fluids are proposed, which significantly reduce the coefficient of friction when rolling steel. Product Description popup.authors Avdeenko Anatoly P. Apuhtina Nadiya V. Konovalova Svitlana O. Lusenko Olena M. Marchenko Inna L. Pirozhenko Volodymyr V. Santalova Anna O Kholmovoi Yuri P. Yusina Anna L. popup.nrat_date 2022-03-09 Close