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Information × Registration Number 0222U002313, 0121U100305 , R & D reports Title Endothelial dysfunction, hypercoagulation and microvascular thrombosis in COVID-19: implications for risk assessment, pathogenesis, and diagnosis popup.stage_title Head Korda Mykhailo M., Доктор медичних наук Registration Date 11-02-2022 Organization Ternopil National Medical University named after I. Gorbachevsky of the Ministry of Health of Ukraine popup.description2  GDR report: 62 pages, 70 sources, 8 tables, 12 figures. Endothelial dysfunction, COVID-19, recovery period, SARS-CoV-2, occlusion test, cytokines. The object of study is the pathogenesis of endothelial dysfunction, hypercoagulation and microvascular thrombosis in patients with COVID-19. The aim of the work is to establish molecular mechanisms of endothelial dysfunction, hypercoagulation and vascular thrombosis in persons with COVID-19 of varying severity, by a comprehensive study of endothelial cell production of vasorelaxant and vasoconstrictor factors, the degree of damage to vascular walls, the presence of coagulopathy and thrombophilia, oxidative stress intensity parameters and, as a result, the development of recommendations for risk assessment and prevention and prognostic and diagnostic criteria for thrombosis and endothelial dysfunction in patients with COVID-19. Research methods - clinical, biochemical, enzyme-linked immunosorbent assay, instrumental, mathematical and statistical. It was found that patients with COVID 19 had a high proportion of concomitant hypertension (AH) - 46.2% and diabetes mellitus (DM) (163 people, 17.6%), which significantly aggravate the course of coronavirus disease. Among the dead, the percentage of patients with concomitant hypertension was 75.0% (51 of 68, p <0.0001). Correlation analysis confirmed a significant effect of age on the severity of COVID-19 (r = 0.485, p <0.0001), the presence of concomitant hypertension (r = 0.471, p <0.0001) and diabetes mellitus (r = 0.346, p <0.0001 ), as well as the duration of history of hypertension (r = 0,394, p <0,0001) and the presence of its complications (r = 0,261, p <0,0001) and ultimately - mortality (r = 0,302, p <0,0001 ). Patients with comorbid hypertension were significantly more likely to require non-invasive (p = 0.018) and invasive (p = 0.022) oxygen therapy. Product Description popup.authors popup.nrat_date 2022-03-09 Close