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Information × Registration Number 0222U002427, 0117U004039 , R & D reports Title Mechanisms of interaction of biologically active substances and electromagnetic fields of EHF range with magnetic nanoparticles, biopolymers and cells popup.stage_title Head Shestopalova Ganna V., Доктор фізико-математичних наук Registration Date 13-02-2022 Organization O. Ya. Usikov Institute for Radiophysics and Electronics NAS of Ukraine popup.description2  The new method is proposed, the results of which allow one to establish the possibility of using superparamagnetic Fe3O4 nanoparticles (SPION) as promising nanosorbents for the removal of dyes from the water environment and as the nanocontainers for targeted drug delivery. It was shown that targeted therapy using SPION as a nanocontainer did not require increasing the dose of the anticancer antibiotic doxorubicin to achieve a therapeutic effect. The dependence of the characteristics of the patterns formed on the surface of films obtained by drying solutions of biopolymers on the structural state of biopolymers in the solutions and factors influencing these processes were determined. The changes in the dielectric constant were revealed by the method of microwave dielectrometry for erythrocyte suspension of patients with common dermatoses with sensitization to certain allergens. The high correlation of dielectric parameters with biochemical data was determined. This allows one to use the dielectric permeability as a criterion of a rapid screening test to determine sensitization to various allergens. Molecular-dynamic modeling of the SARS-CoV-2 coronavirus spike-glycoprotein receptor-binding domain RBD in complex with antiviral drugs has shown that drugs for hepatitis C treatments ledipasvir and paritaprevir (neutral form) in combination with the natural biflavonoid amentoflavone are the promising candidates to block the binding site of RBD on ACE2 cell receptor responsible for SARS-CoV-2 entry into the host cell. The original Protein-Nucleic Acid Structural Database with Information on the Accessible Surface Area (ProtNA-ASA, free available http://www.ire.kharkov.ua/ProtNA-ASA) is updated. The ProtNA-ASA contains information on the structure of free DNA, DNA in the protein-nucleic complexes, the accessible surface area of DNA atoms, and the values of the electrostatic potential of the DNA double helix. Product Description popup.authors Bereznyak Katerina G. Bliznyuk Yuliya M. Gladkovskaya Nataliya A. Glibitskiy Gennadiy M. Glibitskiy Dmitriy M. Dukhopelnikov Evgen V. Zhitnikova Mariya Y. Kashpur Vsevolod A. Kolesnikov Vladimir G. Miroshnychenko Katerina V. Semenov Мichail A. Skuratovska Anastasiya A. Khmil Nataliya V. Khorunzhaya Olga V. Khrebtova Anna S. Shestopalova Ganna V. popup.nrat_date 2022-03-09 Close