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Information × Registration Number 0222U002524, 0112U000061 , R & D reports Title Physiological and biochemical aspects of adaptation of living organisms to unfavourable environmental conditions popup.stage_title Head Lushchak Volodymyr Ivanovych, Доктор біологічних наук Registration Date 14-02-2022 Organization Kolomyia Educational-Scientific Institute The Vasyl Stefanyk Precarpathian National University popup.description2 KEY WORDS: FRUIT FLY, BAKER’S YEAST, FISH, OXIDATIVE STRESS, HERBICIDES, ADAPTOGENS, HORMESIS. Subject of the research is metabolic systems and intracellular signaling systems that allow organism to adapt to the action of xenobiotics and transition metals, deficit and excess of components of a diet or growth medium such as proteins, specific organic acids and carbohydrates. The aim of the work is to determine the main targets and indicators of a number of environmental factors (xenobiotics, transition metals, excess and deficit of proteins, certain organic acids and carbohydrates), confirm or deny the ability of small doses of toxic substances to increase the adaptive capacity of living organisms. It has been found that herbicides 2,4-dichlorophenoxyacetic acid (2,4-D), metribuzin and mancozeb cause oxidative stress in the liver and kidney of fish, leading to disruption of the structure of these tissues. However, it was found that 2,4-D in low concentrations increases resistance of baker's yeast to oxidants. It has been shown that increasing the amount of the amino acid arginine in the diet of fruit flies accelerates their development and increases the adaptive potential. Alpha-ketoglutaric acid (aKG) has been shown to increase the resistance of fruit flies to ethanol. Presence of aKG in the growth medium also increases the resistance of yeast cells to hydrogen peroxide. This organic acid also increases the resistance of fruit flies to cold and heat stresses. Sodium molybdate and chromate have been shown to act as insulin mimetics at low concentrations whereas intensify free radical processes at high concentrations. It has been found that fructose, compared to glucose, can be a more powerful factor of carbonyl and oxidative stresses. However, defects in the signaling pathway regulated by the TOR protein (target of rapamycin) increase lifespan of the yeast growing on fructose. Product Description popup.authors Abrat Oleksandra B. Bailiak Mariia M Gospodaryov Dmytro V. Gusak Victor Vasyljovych Lushchak Volodymyr Ivanovysh Lushchak Oleh V. Mosiychuk Nadia Mykhailivna Semchyshyn Halyna M popup.nrat_date 2022-03-09 Close