Search academic texts

Information × Registration Number 0222U002568, 0119U002014 , R & D reports Title Study of biological properties of museum and modern strains of conditionally pathogenic microorganisms - pathogens of wound infections. popup.stage_title Head Pokas Olena V., Registration Date 14-02-2022 Organization State Institution "LV Gromashevsky Institute of Epidemiology and Infectious Diseases of the National Academy of Medical Sciences of Ukraine" popup.description2  The leading pathogens of wound infections in patients of the surgical department of the Kyiv Regional Hospital - CNS (19.5%), S. aureus (23.9%) and E. coli (17.8%) were identified. Among staphylococci of wound infections, a significant proportion of strains with methicillin-resistant phenotype were found: MRSA - 25.9 ± 8.4%, CNS - 54.5 ± 10.6%. Among enterobacteria, beta-lactamase-producing strains of different types were identified: ES?L - 31.8 ± 7.0% of strains, AmpC - 2.3 ± 2.3%; KPC - 11.4 ± 4.8% of strains; 4.5 ± 3.1% showed combined phenotypes. Beta-lactamase-producing strains were highly resistant to clinically important groups of antibiotics, beta-lactams and fluoroquinolones. Among NFGNB 64.3 ± 12.8% of P. aeruginosa strains were producers of M?L. It was found that aminoglycosides had the highest activity against the studied enterobacteria and NFGNB-beta-lactamase producers, and the most effective drugs against specific pathogens were different depending on the phenotype of resistance. Carbapenems (60.0-100.0%) retain clinical efficacy against non-beta-lactamase-producing strains. During the reporting period, we continued to monitor the prevalence of strains producing clinically important types of beta-lactamases among multidrug-resistant pathogens of nosocomial infections. It was found that among the multi-resistant strains of enterobacteria studied by us, the most common types of beta-lactamases were ES?L - 63.3 ± 3.8%; KPC - 20.2 ± 7.3%; AmpC - in 10.0 ± 5.0% of strains. Combined phenotypes were 13.3%. Among the multidrug-resistant strains of NFGNB isolated from patients with surgical profile, 70.6 ± 11.0% of P. aeruginosa strains and 44.4 ± 9.6% of A. baumannii strains were producers of M?L. Among the museum strains of enterobacteria isolated in the period from 1999 to 2020 in different regions of Ukraine, we found 47.3 ± 4.4% of strains producing ES?L, 7.7 ± 2.4% producing cephalosporinase C and carbapenemase (KPC) - 10, 1 ± 2.7%. 5 strains had a comb Product Description popup.authors popup.nrat_date 2022-03-09 Close