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Information × Registration Number 0222U002784, 0117U000989 , R & D reports Title Creation of redox-active nanomaterials with luminescent detection of activity state for biomedical and industrial applications. popup.stage_title Head Semynozhenko Volodymyr P., Доктор фізико-математичних наукSorokin Oleksandr V., Доктор фізико-математичних наук Registration Date 15-02-2022 Organization Institute for scintillation materials NAS Ukraine popup.description2 It was shown for the first time that the mechanism of antioxidant action of nanocrystalline cerium dioxide (CeO2-x) is associated with the diffusion of oxygen in one-dimensional vacancy pores. It is shown that irradiation of aqueous solutions of CeO2–x nanocrystals with radiation with wavelengths corresponding to charge transfer absorption (O2– → Ce4+) after the end of the ROS decomposition process accelerates the restoration of the initial Ce3+/Ce4+ ratio (and, consequently, antioxidant activity). The ability of nanoparticles to interfere with the regulation of redox processes in biosystems and, depending on the concentration, to have a cytotoxic effect was determined. Characteristic conditions and concentrations of nanoparticles under which only the corrective or protective effect of nanoparticles is revealed. It has been proved that orthovanadate grain-like nanoparticles have the most significant antioxidant effect in various model systems, and at the body level, along with a number of positive effects have anti-aging effects. The mechanisms of this effect related to the regulation of oxidative balance and glutathione metabolism of an aging organism have been studied. The model of accelerated aging of rats (overeating at an early age, which leads to persistent hormonal and metabolic disorders) shows the ability of nanoparticles of gadolinium orthovanadates to correct significant disturbances of physiological, biochemical processes and oxidative balance, accompanied by increased life expectancy and improved quality of life. A laboratory site for the production of redox-active nanomaterials for biomedical use has been established. The influence of strong exciton-phonon interaction on the spectral characteristics of J-aggregates formed in different types of polymer films has been established. It is shown that cyanine dye J aggregates can be used as photosensitizers for Graetzel solar cells due to their high extinction coefficients. Product Description popup.authors Bespalova Iryna I. Kavok Natalia S. Seminko Vladyslav V. Semynozhenko Volodymyr P. Sorokin Oleksandr V. popup.nrat_date 2022-03-09 Close