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Information × Registration Number 0222U002825, 0117U001078 , R & D reports Title The application of mathematical methods for studying the physical and chemical processes in biotechnical systems popup.stage_title Head Lychkovskyi Eduard I, Registration Date 15-02-2022 Organization Danylo Halytsky Lviv National Medical University popup.description2  The degree of similarity of transmembrane potentials was quantitatively characterized by cross-correlation analysis. The distribution of fluctuations of cross-correlation functions with complex dynamics, which occur during time shifts in both forward and reverse directions, has been established. It is established that at large values ​​of time shifts, the cross-correlation coefficient is an uninformative indicator, as information about the influence of the factor on the living system is lost. A mathematical model is constructed to determine the change in the greatest influence of a certain type of ions on the value of the transmembrane potential of the germ cell. The decrease in the strength of correlations between the individual elements of the system with increasing magnitude of the time shift. Inhibition of activity of ubain-sensitive Na +, K + -ATPase, Ca2 +, Mg2 + -ATPase of spermatozoa of infertile men with various forms of pathospermia was revealed. The inhibitory effect of H2O2 and calix [4] arena C-107 on the main kinetic parameters of ATP hydrolysis with the participation of Na +, K + -ATPase and Ca2 +, Mg2 + -ATPase was studied. Using spectrofluorimetry, Ca2 + signals in male sperm were studied by in vitro incubation with progesterone, 4-aminopyrimidine and tetraethylammonium. An increase in the content of TBA-positive products and depletion of the compensatory mechanisms of the glutathione antioxidant system in the sperm of infertile men have been revealed. The influence of radical and non-radical types of reactive oxygen species on glutathione-S-transferase activity and the content of lipoperoxidation products in spermatozoa of infertile men has been investigated. The concept of interaction of cholesteric liquid crystals with creatinine, urea, urease, trypsin, cholesterol, amino acids and NO2 in order to create the material of the active medium of the optical sensor of biological substances is considered. Product Description popup.authors Vistak Mariia Volodumyrivna Halyk Halyna Vasylivna Malanchuk Oksana Mykhailivna Meskalo Olha Ivanivna Turyanska Lesya Mykhailivna Fafula Roman Volodymyrovych Fedorovych Zoryana Yaroslavivna popup.nrat_date 2022-03-09 Close