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Information × Registration Number 0222U003054, 0119U001420 , R & D reports Title The role of hormonal and metabolic predictors in the formation and development of diabetic retinopathy popup.stage_title Head Tovkai Oleksandr Andriiovych, Доктор медичних наук Registration Date 17-02-2022 Organization Ukrainian Scientific and Practical Center for Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine popup.description2  According to the results of scientific work, it was found that the hormones of adipose tissue are directly involved in the formation and progression of diabetic retinopathy. For the first time on a mathematical model for assessing the risk of progression of diabetic retinopathy, the prognostic significance of metabolic syndrome clusters and the diagnostic value of adipose tissue hormones, chemokines in the occurrence and development depending on the stage of diabetic retinopathy were established, the type of modifying effect of predictors was determined. It was shown in the study of morphometric and biochemical clusters of the metabolic syndrome using ANOVA and discriminant analysis that fasting hyperglycemia, low-density lipoprotein cholesterol in the blood and the duration of type 2 diabetes from the moment of diagnosis have the greatest influence on the progression of diabetic retinopathy. It was found that clusterin is not associated with both the risk of a high thickness of the nerve fiber layer, the ganglion cell layer, the inner boundary layer, the central retinal thickness, the minimum thickness of the fovea, the volume of the macula and the fovea, low visual acuity, and the risk of deterioration of the macula in patients with type 2 diabetes with diabetic macular edema. A method for assessing the risk of progression of diabetic retinopathy in patients with type 2 diabetes mellitus and obesity with the determination of markers of the metabolic syndrome and leptin in blood serum has been put into practice. Product Description popup.authors Ischuk Vadim Vasylovych Kyryliuk Mykhailo L. Singh Kanwarjit S Tretyak Olena Е popup.nrat_date 2022-03-09 Close