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Information × Registration Number 0222U003484, 0121U109986 , R & D reports Title Development of technology for the use of water-soluble C60 fullerenes to reduce skeletal muscle fatigue popup.stage_title Head Prylutskyi Yurii I., Доктор фізико-математичних наук Registration Date 03-04-2022 Organization Taras Shevchenko National University of Kyiv popup.description2 The object of study is muscle fatigue. The aim of the study was to determine the effect of C60 fullerenes on muscle fatigue. Research methods - strain gauge analysis. Toxicological studies have shown that the LD50 for female and male Wistar Han rats of water-soluble C60 fullerene (0.15 mg / ml) orally in excess of 15 ml / kg body weight and according to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) for acute oral toxicity belongs to the 5th category of toxicity. Water-soluble C60 fullerene (0.15 mg / ml) does not have a sensitizing effect on the body of ants and in accordance with the requirements of the GHS is not classified as a contact sensitizer. As a result of mechanokinetic studies, it was found that water-soluble C60 fullerene at a dose of 0.5 mg / kg in the prophylactic scheme (1 h before the initiation of muscle fatigue) reduces the recovery time of the strength response of the flounder rat (after its exhaustion), prolongs the duration of its active functioning (endurance) and has a more effective effect on homeostasis of muscle tissue compared to the known exogenous antioxidants N-acetylcysteine ​​and β-alanine. The results of the correction of muscle fatigue do not depend on the method of administration of water-soluble C60 fullerenes. A positive change in the studied biomechanical parameters of skeletal muscle contraction - markers of fatigue - by action water-soluble C60 fullerenes confirms the possibility of their use as effective therapeutic monoagents or in new pharmaceuticals that can reduce the severity of muscle damage and correct pathological conditions of the muscular system, which is based on the action of free radical processes.  Product Description popup.authors Bogutska Catherine I. Honchar Olga О. Nozdrenko Dmytro M. Pampuha Ihor V. popup.nrat_date 2022-04-03 Close