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Information × Registration Number 0222U003670, 0117U006961 , R & D reports Title Targeted search of biologically active compounds among annelated quinazoline and pteridine derivatives popup.stage_title Head Kovalenko Sergiy I, Доктор фармацевтичних наук Registration Date 12-05-2022 Organization Zaporizhzhya State Medical University popup.description2  Object of research: Acylation reactions, hydrazinolysis, nucleophilic and electrophilic substitution reactions, nucleophilic addition-cleavage, heterocyclization and condensation in a number of quinazoline and pteridine derivatives. Physicochemical, quantum chemical and biological biological properties of synthesized compounds. Correlation dependence "structure-activity". More than 200 new compounds have been synthesized, including substances with a high inhibitory effect on 2,2-diphenyl-1-pyrylhydrazyl (DPPH), lipoxygenase, dehydrofolate reductase. They were found to exhibit anti-inflammatory, actoprotective, hypoglycemic, antibacterial, antitumor activity, certain patterns of structure-activity, and critical "pharmacoform" fragments responsible for certain biological actions. Product Description popup.authors Antypenko Oleksii Mykolayovych Berest Halyna Hryhorivna Voskoboinik Oleksii Yuriyovych Kazunin Maksim Stanislavovich Kandybei Kostiantyn Ivanovych Moskalenko Oleksandra Serhiivna Nosulenko Inna Stepanivna Stavytskyi Viktor Valeriiovych Kholodniak Serhii Valeriiovych Shabelnyk Kostiantyn Petrovych Shubina Yuliia Viktorivna popup.nrat_date 2022-05-12 Close