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Information × Registration Number 0222U003726, 0121U110084 , R & D reports Title To study the effectiveness of organ-preserving surgical tactics for the treatment of kidney cancer, to optimize the indications and medical rehabilitation of patients. popup.stage_title Head Stakhovsky Eduard O., Доктор медичних наук Registration Date 25-05-2022 Organization National Cancer Institute popup.description2  Object of study: patients with kidney cancer. Research methods: general clinical, functional, laboratory, pathomorphological, instrumental, radiological (ultrasound, CT, MRI, radioisotope rheography), statistical. The effectiveness of treatment will be assessed by the number of organ-sparing operations, the number and complexity of intra- and postoperative complications according to the Clavien-Dindo classification, the duration of the operation, the level of blood loss and postoperative bed-day. Based on a randomized prospective study of 126 patients with localized NKR who underwent kidney resection, it was found that the multimodal program "fast-track surgery" supplemented by rejection of central thermal renal ischemia, restoration of the integrity of the renal parenchyma allows to reduce the postoperative bed-day to 3.5 (p <0.001) with a similar level of perioperative complications (x2 = 0.67; p = 0.41). A retrospective cohort analysis of 109 patients with metastatic NKR found that cytoreductive kidney resection in patients with metastatic NKR did not significantly affect the overall survival rate (Kaplan-Meier Test: p = 0.093) compared with cytoreductive nephrectomy, but 7 cumulative survival was higher in the group of organ-sparing treatment (7.3 ± 3.9% vs. 23.9 ± 6.3%). It has also been shown that cytoreductive kidney resection in patients with metastatic NKR significantly reduces the risk of death compared with cytoreductive nephrectomy (p = 0.037), HR = 0.62 (95% CI 0.39 - 0.97), without affecting the level of postoperative complications , blood loss and duration of postoperative bed-day (p> 0.05). Product Description popup.authors Vitruk Iurii V. Voylenko Oleg А. Kononenko Oleksiy A. Stakhovsky Olexander E popup.nrat_date 2022-05-25 Close