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Information × Registration Number 0222U004621, 0119U101219 , R & D reports Title Study of cell-molecular mechanisms of pharmacological influence on the reprogramming of тхе macrophages functional phenotype in the regeneration of the wound on the background of hyperglycemia popup.stage_title Head Natrus Larysa V., Доктор медичних наук Registration Date 21-09-2022 Organization Bogomolets National Medical University popup.description2  With prolonged uncorrected hyperglycemia in the regeneration of connective tissue accumulates glycation products - AGEs, which are resistant to degradation of metalloproteases, which changes the properties of the extracellular matrix (PCM), delays the active migration of endothelial cells and keratinocytes, enhances prophylactic leukocytosis etc. Against the background of hyperglycemia NO is inactivated by oxygen free radicals with the formation of peroxynitrite, inhibits the expression of iNOS, which reduces the bioavailability of NO, increases oxidative-nitrosative stress and inhibits the positive effects of NO on the healing process. The use of enzyme-containing nanoparticles of IFP provides effective degradation of glycosylated components of PKM, while reducing the activity of MMP-2, does not aggravate oxidative-nitrosative stress in the wound, which reduces inflammation and more effective healing of burns in rats with streptococcus. Product Description popup.authors popup.nrat_date 2022-09-21 Close