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Information × Registration Number 0222U004624, (0121U107940) , R & D reports Title Development of a new concept of diagnostic algorithm for mental disorders of the autism spectrum in children for pathogenetic justification of correction of the condition by immunotherapy popup.stage_title Розробка нової концепції діагностичного алгоритму психічних розладів спектру аутизму у дітей для патогенетичного обґрунтування корекції стану шляхом імунотерапії Head Natrus Larysa V., Доктор медичних наук Registration Date 21-09-2022 Organization Bogomolets National Medical University popup.description1 Having studied the pattern of biochemical disorders caused by genetic deficiency of the folate cycle, and related immune dysfunction to characterize the mechanisms of immune-dependent brain damage, deepening understanding of the pathogenesis of encephalopathy in children with autism spectrum disorders, and on the basis of immunotherapy aimed at suppressing the main mechanisms of cerebral damage with the achievement of the effect of neuroprotection. popup.description2  The selection of a new clinical nosology in the field of medical genetics - genetic deficiency of the folate cycle (GDFC) - as an independent genetic metabolic disease, rather than as a risk factor. In the field of clinical immunology - primary immunodeficiency associated with GDFC, which adds to the list of currently known primary immunodeficiencies in humans and justifies neuroprotective immunotherapeutic interventions. It is recommended for children with autism spectrum disorders (ASD) associated with GDFC to study the biochemical status of a certain list of tests, to assess immune status, microbiological tests, rheumatological tests to assess autoimmunity to brain and extracerebral autoantigens. Based on the identified correlations between the obtained indicators, diagnose a special form of primary immunodeficiency, which requires and justifies neuroprotective immunotherapeutic interventions to reduce the manifestations of ASD in children. Product Description popup.authors popup.nrat_date 2022-09-21 Close