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Information × Registration Number 0222U004719, 0118U007343 , R & D reports Title Molecular, genetic and pharmacological agents of influence on cellular mechanisms of neurological disorders. popup.stage_title Head Kryshtal Oleg О., д.б.н. Registration Date 20-10-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  Curcumin has been shown to enhance α7-nAChR activity in neurons of the central nervous system, mitigate impaired levels of oxidative stress, and alleviate autism spectrum disorder-like behaviors in BTBR mice. Stimulation of α7-nAChR has a potential beneficial effect on the future pharmacological treatment of this pathology. The activating effect of liposomal NO on ВКСа channels can be explained by the destabilization of the closed conformation of the channel molecule, which causes its more frequent opening and, accordingly, increases the probability of the channel transitioning to the open state. The obtained results are of high importance regarding the development of drugs against arterial hypertension and other diseases. Application of the membrane receptor modulators capsaicin, SR141716, N-Allylnoroxymorphone, EN-2234A causes an increase in vagal fiber signaling, while menthol application slightly decreases vagal electrical activity. These facts can be used in the development of the modern methods of treatment of acute respiratory distress syndrome. GCaMP6m-GFP-expressing cells of a number of neural structures in the brain of young chum (Oncorhynchus keta) belong to a neuron-specific cell lineage, indicating neuronal expression of the mammalian adenovirus receptor homologue in young chum neurons. A set of classified EEG epochs of mice containing various forms of paroxysmal activity was created. Product Description popup.authors Isaiev Dmytro S. Maksymiuk Oleksandr P. Prudnikov Ihor M. Storozhuk Maksim V. Cherninsky Andrij O. Chyzhmakov Ihor V. popup.nrat_date 2022-10-20 Close