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Information × Registration Number 0222U004730, 0118U007351 , R & D reports Title Ion channels - receptors of physical and chemical cues in regulation of excitation-contraction of visceral muscles in norm and pathology popup.stage_title Head Shuba Yaroslav М., Доктор біологічних наук Registration Date 20-10-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  It was shown that cardiac-type K ATP channels with a subunit structure of Kir6.2/SUR2A are more sensitive to the known activator of these channels, pinacidil, compared to its domestic, fluorine-containing analogue, flokalin. Adding fluorine to the structure of the pinacidil molecule reduces its effectiveness in terms of activating K ATP channels. In this regard, the better cardioprotective action of flocalin is explained by its possible additional pharmacological properties: partial blocking of the voltage- dependent calcium entry in cardiomyocytes, as well as the features of pharmacodynamics and pharmacokinetics at the level of the whole organism. Product Description popup.authors Yelyashov Semen I. Kravchuk Danyla I. Sotkis Anna V. Stoliar Liubov A. Filipov Igor B. Sharopov Bizhan R. popup.nrat_date 2022-10-20 Close