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Information × Registration Number 0222U004807, 0118U007348 , R & D reports Title The role of long non-coding RNA in the development of experimental and clinical pathology popup.stage_title Head Dosenko Victor Ye., Доктор медичних наук Registration Date 03-11-2022 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  With the use of modern molecular genetic approaches, in studies performed on rats with chronic myocardial infarction, it was shown that under the conditions of infarction, the content of lncRNA H19 decreased almost by half, and the expression level of lncRNA TUG1 increased by almost two times. In the study on the culture of neonatal cardiomyocytes under the conditions of PEX14 gene interference, no significant changes in GAS5 lncRNA expression were found between the Scr and antiPEX14 groups. Under the conditions of activation of PPAR receptors and the development of diabetes, the level of long non-coding RNA MIAT and TUG1 significantly decreases. It was determined that lncRNAs such as Abcc8.fSep08-unspliced, Abcc8.cSep08-unspliced and Abcc8.bSep08 can be regulators of the expression of the ABCC8 gene, which encodes the regulatory subunit of SUR1 K ATP channels. It was shown that total RNA and RNA of the small fraction in different concentrations induce NETs. Product Description popup.authors Honcharov Serhiy V. Drevytska Tetyana I. Zhukovska Anna S. Kozak Taisiya O. Laguta Tetyana I. Lapikova-Briginska Tetyana Yu. Morgachev Roman O. Nagibin Vasyl S. Panasyuk Olga S. Pashevin Denys O. Polishchuk Valentina O. Portnichenko Heorhiy V. Serebrovska Zoia O. Stroy Dmitro О. Strutynskyi Ruslan B. Tumanovska Lesia V. Hetsuriani Mykhaylo R. Shysh Anzhela M. popup.nrat_date 2022-11-03 Close