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Information × Registration Number 0222U005411, 0120U103301 , R & D reports Title Grounding of the choice of resection or ablation treatment of colorectal cancer metastases in the liver, taking into account the systemic inflammation predictors popup.stage_title Head Sorochan Pavel P., Кандидат медичних наук Registration Date 29-12-2022 Organization State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine" popup.description2 Object of the study: surgical resection and radiofrequency ablation of colorectal cancer metastases in the liver (18 people). Purpose: to develop criteria for choosing surgical resection or radiofrequency ablation of metastatic liver lesions in colorectal cancer based on the selection of immune and biochemical predictors of the systemic inflammatory response. Methods and equipment: immunological, hematological, biochemical, clinical, morphological, statistical methods; light microscopes, flow cytofluorimeter, spectrophotometer, hematological, and immune enzyme analyzers. Theoretical and practical results: immune and hematological indicators of the inflammatory response after radiofrequency ablation (RFA) of colorectal cancer metastases in the liver were established. 3 days after RFA, an increase in the number of leukocytes, the H/L index, a decrease in the level of hemoglobin and the number of eosinophils, a violation of the balance of CD4+ and CD8+ lymphocytes, a decrease in the number of NK and NKT cells and the expression of the activating NK cell receptor NKp46, an increase in the percentage of CD3 +HLA-Dr+-, CD4+ PD1+-, CD8+PD1+-cells, levels of CRP, IL-6, ferritin and HOMA-IR index. On day of 14, most of the indicators were approached to the RF, except for the preservation of reduced hemoglobin levels, NK- and NKT cells and increased platelet levels. Comparative analysis with the data obtained after resection of metastases in the liver revealed less than the severity and duration of the inflammatory response during RFA. Novelty: the complex of indicators on the basis of the subpopulation composition of lymphocytes, markers of functional activity of T- and NK cells and biochemical markers of inflammatory reaction caused by RCA or surgical treatment, which are involved in pathogenetic mechanisms that contribute to the progression of cancer. Implementation efficiency: improving the effectiveness of treatment. Field of application: oncology, clinical immunology.  Product Description popup.authors Ivanenko Maryna Olehivna Balaka Svyatoslav Mykolaiovych Bublyk Vitalii Vasylovych Hromakova Inna Serhiivna Hromakova Iryna Andriivna Kosheleva Iryna Viktorivna Kuzmenko Olena Viktorivna Lepekha Ivanna Vitaliivna Olkhovsky Dmitry Vasiljevich Podrez Eduard Volodymyrovych Polozova Mariia Volodymyrivna Prokhach Nataliia Eduardivna Revenkova Svitlana Ivanivna Tepla Viktoriia Oleksandrivna Tretiak Maryna Yuriivna Chekanova Svitlana Vasylivna popup.nrat_date 2022-12-29 Close